Synergistic Signaling of KRAS and Thyroid Hormone Receptor β Mutants Promotes Undifferentiated Thyroid Cancer through MYC Up-Regulation

Undifferentiated thyroid carcinoma is one of the most aggressive human cancers with frequent RAS mutations. How mutations of the RAS gene contribute to undifferentiated thyroid cancer remains largely unknown. Mice harboring a potent dominant negative mutant thyroid hormone receptor β, TRβPV (ThrbPV/...

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Үндсэн зохиолчид:	Xuguang Zhu, Li Zhao, Jeong Won Park, Mark C. Willingham, Sheue-yann Cheng
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Elsevier 2014-09-01
Цуврал:	Neoplasia: An International Journal for Oncology Research
Онлайн хандалт:	http://www.sciencedirect.com/science/article/pii/S1476558614001092
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!