Synergistic Signaling of KRAS and Thyroid Hormone Receptor β Mutants Promotes Undifferentiated Thyroid Cancer through MYC Up-Regulation

Undifferentiated thyroid carcinoma is one of the most aggressive human cancers with frequent RAS mutations. How mutations of the RAS gene contribute to undifferentiated thyroid cancer remains largely unknown. Mice harboring a potent dominant negative mutant thyroid hormone receptor β, TRβPV (ThrbPV/...

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Bibliographic Details

Main Authors:	Xuguang Zhu, Li Zhao, Jeong Won Park, Mark C. Willingham, Sheue-yann Cheng
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2014-09-01
Series:	Neoplasia: An International Journal for Oncology Research
Online Access:	http://www.sciencedirect.com/science/article/pii/S1476558614001092
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