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Insight into motor fatigue mechanisms in natalizumab treated multiple sclerosis patients with wearing off

Abstract Motor fatigue in Multiple Sclerosis (MS) is due to reduced motor cortex (M1) output and altered sensorimotor network (SMN) modulation. Natalizumab, a disease-modifying therapy, reduces neuroinflammation and improves fatigue. However, some patients treated with natalizumab experience fatigue...

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Glavni autori: Giorgio Leodori, Marco Mancuso, Davide Maccarrone, Matteo Tartaglia, Antonio Ianniello, Francesco Certo, Gina Ferrazzano, Leonardo Malimpensa, Daniele Belvisi, Carlo Pozzilli, Alfredo Berardelli, Antonella Conte
Format: Artigo
Jezik:Inglês
Izdano: Nature Portfolio 2024-07-01
Serija:Scientific Reports
Teme:
Motor fatigue
Natalizumab
Wearing-off
Neurophysiology
TMS-EEG
Sensorimotor network
Online pristup:https://doi.org/10.1038/s41598-024-68322-w
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