Insight into motor fatigue mechanisms in natalizumab treated multiple sclerosis patients with wearing off

Abstract Motor fatigue in Multiple Sclerosis (MS) is due to reduced motor cortex (M1) output and altered sensorimotor network (SMN) modulation. Natalizumab, a disease-modifying therapy, reduces neuroinflammation and improves fatigue. However, some patients treated with natalizumab experience fatigue...

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Autors principals:	Giorgio Leodori, Marco Mancuso, Davide Maccarrone, Matteo Tartaglia, Antonio Ianniello, Francesco Certo, Gina Ferrazzano, Leonardo Malimpensa, Daniele Belvisi, Carlo Pozzilli, Alfredo Berardelli, Antonella Conte
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-07-01
Col·lecció:	Scientific Reports
Matèries:	Motor fatigue Natalizumab Wearing-off Neurophysiology TMS-EEG Sensorimotor network
Accés en línia:	https://doi.org/10.1038/s41598-024-68322-w
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