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Bacterial secondary metabolites as resistance-modifying adjuvants: microbial origins, molecular mechanisms, and translational relevance

The accelerating crisis of antimicrobial resistance (AMR) necessitates strategies that extend beyond the continual discovery of new conventional antibiotics. Bacterial secondary metabolites, historically valued as sources of antimicrobial scaffolds, are increasingly recognized for their roles as res...

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Principais autores: Victor Uchenna Chigozie, Charles Okechukwu Esimone
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-04-01
Serier:Frontiers in Microbiology
Fag:
antibiotic adjuvants
antimicrobial resistance (AMR)
bacterial secondary metabolites
biofilm disruption
biofilm-associated tolerance
efflux pump inhibition
Online adgang:https://www.frontiersin.org/articles/10.3389/fmicb.2026.1779022/full
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