Bacterial secondary metabolites as resistance-modifying adjuvants: microbial origins, molecular mechanisms, and translational relevance

The accelerating crisis of antimicrobial resistance (AMR) necessitates strategies that extend beyond the continual discovery of new conventional antibiotics. Bacterial secondary metabolites, historically valued as sources of antimicrobial scaffolds, are increasingly recognized for their roles as res...

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Autors principals:	Victor Uchenna Chigozie, Charles Okechukwu Esimone
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2026-04-01
Col·lecció:	Frontiers in Microbiology
Matèries:	antibiotic adjuvants antimicrobial resistance (AMR) bacterial secondary metabolites biofilm disruption biofilm-associated tolerance efflux pump inhibition
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fmicb.2026.1779022/full
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