Kynurenine-AhR-SLC39A10-Zn2+ signaling reprograms macrophages and enhances pirfenidone efficacy in pulmonary fibrosis

Abstract Background Pulmonary fibrosis (PF) is an irreversible and lethal lung disease characterized by progressive scarring lacking safe and effective treatment options. Recent studies have underscored the role of macrophage polarization in fibrotic progression, yet the role of kynurenine (Kyn), a...

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Hlavní autoři:	Huihui Yue, Ruihan Dong, Jianhan He, Fengqin Zhang, Yan Fan, Xinran Dou, Qing Zhou, Xuan Li, Long He, Shu Zhang, Qilin Yu, Weikuan Gu, Jianping Zhao, Yi Wang, Cong-Yi Wang, Huilan Zhang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2026-04-01
Edice:	Cell Communication and Signaling
Témata:	Pulmonary fibrosis Tryptophan metabolism Kynurenine Macrophages
On-line přístup:	https://doi.org/10.1186/s12964-026-02900-5
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