Kynurenine-AhR-SLC39A10-Zn2+ signaling reprograms macrophages and enhances pirfenidone efficacy in pulmonary fibrosis

Abstract Background Pulmonary fibrosis (PF) is an irreversible and lethal lung disease characterized by progressive scarring lacking safe and effective treatment options. Recent studies have underscored the role of macrophage polarization in fibrotic progression, yet the role of kynurenine (Kyn), a...

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Egile Nagusiak:	Huihui Yue, Ruihan Dong, Jianhan He, Fengqin Zhang, Yan Fan, Xinran Dou, Qing Zhou, Xuan Li, Long He, Shu Zhang, Qilin Yu, Weikuan Gu, Jianping Zhao, Yi Wang, Cong-Yi Wang, Huilan Zhang
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	BMC 2026-04-01
Saila:	Cell Communication and Signaling
Gaiak:	Pulmonary fibrosis Tryptophan metabolism Kynurenine Macrophages
Sarrera elektronikoa:	https://doi.org/10.1186/s12964-026-02900-5
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