Comparing alignment and de-novo approaches for gut microbiota metagenomic data analysis reveals differences in taxonomic resolution and novel functional insights

Abstract Microbiome annotation based on metagenomic data is primarily conducted using two global approaches: alignment-based approach (AL) and de novo approach (DN). This study aimed to evaluate the limitations of each approach, explore correlations between their results, and assess the equivalence...

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主要な著者:	Polina Kuzmichenko, Dmitry Fedorov, Julia Galeeva, Anna Postoeva, Ekaterina Krieger, Alexander Kudryavtsev, Alexander Pavlenko, Andrey Vvedensky, Elizaveta Starikova, Vadim Govorun, Elena Ilina
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-11-01
シリーズ:	Scientific Reports
主題:	Microbiome de-novo assembly Alignment,2,5-diketo-D-gluconate reductase A Alistipes onderdonkii
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-26617-6
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