α1-adrenoceptor ligands inhibit chemokine receptor heteromerization partners of α1B/D-adrenoceptors via interference with heteromer formation

We reported previously that α1-adrenoceptor (α1-AR) ligands inhibit chemokine receptor (CR) heteromerization partners of α1B/D-AR. The underlying mechanisms are unknown and in vivo evidence for such effects is missing. Utilizing CCR2 and α1B-AR as prototypical partners, we observed in recombinant sy...

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Principais autores:	Xianlong Gao, Garrett A. Enten, Michelle Y. McGee, McWayne Weche, Matthias Majetschak
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2023-04-01
Series:	Pharmacological Research
Assuntos:	G protein coupled receptor heteromers Gαi coupling β-arrestin-2 CAMP Receptor internalization Bioluminescence resonance energy transfer
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S1043661823000865
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