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Cell surface GRP78 regulates BACE2 via lysosome-dependent manner to maintain mesenchymal phenotype of glioma stem cells

Abstract Background Glioma stem cells (GSCs) are considered the initial cells of gliomas, contributing to therapeutic resistance. Patient-derived GSCs well recapitulate the heterogeneity of their parent glioma tissues, which can be classified into different subtypes. Likewise, previous works identif...

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Principais autores: Zihang Chen, Huizhi Wang, Zongpu Zhang, Jianye Xu, Yanhua Qi, Hao Xue, Zijie Gao, Rongrong Zhao, Shaobo Wang, Shouji Zhang, Wei Qiu, Xing Guo, Gang Li
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2021-01-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
GRP78
Glioma stem cell
BACE2
Radiation
Mesenchymal subtype
Acesso em linha:https://doi.org/10.1186/s13046-020-01807-4
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