Phosphoinositide 3-Kinase Signaling in the Tumor Microenvironment: What Do We Need to Consider When Treating Chronic Lymphocytic Leukemia With PI3K Inhibitors?

Phosphoinositide 3-kinases (PI3Ks) and their downstream proteins constitute a signaling pathway that is involved in both normal cell growth and malignant transformation of cells. Under physiological conditions, PI3K signaling regulates various cellular functions such as apoptosis, survival, prolifer...

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Κύριοι συγγραφείς:	Ebru Aydin, Sebastian Faehling, Mariam Saleh, Laura Llaó Cid, Martina Seiffert, Philipp M. Roessner
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2021-01-01
Σειρά:	Frontiers in Immunology
Θέματα:	phosphoinositide 3-kinase (PI3K) chronic lymphocytic leukemia tumor microenvironment idelalisib phosphoinositide 3-kinase (PI3K) inhibition
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fimmu.2020.595818/full
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