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BCAA (Branched-Chain Amino Acids) Inhibiting the Autophagy System via the Activation of mTORC1, Thereby Upregulating the Tumor Suppressor PDCD4 in Huh7 Hepatoma Cells

Branched-chain amino acids (BCAAs) are essential amino acids in humans, with reported anti-proliferative effects on HepG2 hepatoma cells and the potential to reduce hepatocellular carcinoma (HCC) development in cirrhotic patients. PDCD4, a tumor suppressor that is downregulated in many cancers, is a...

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Principais autores: Rasheda Perveen, Iwata Ozaki, Hirokazu Takahashi, Md Manirujjaman, Takuya Kuwashiro, Sachiko Matsuhashi
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2025-12-01
coleção:Cells
Assuntos:
BCAA
PDCD4
autophagy
mTORC1
Huh7
Acesso em linha:https://www.mdpi.com/2073-4409/14/24/1975
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