Targeting PAK1 or PAK4 Uncovers Different Mechanisms of Vascular Reprogramming in Pancreatic Cancer

The tumour microenvironment in pancreatic ductal adenocarcinoma (PDA) regulates vascular function and therapeutic response. P21-activated kinases (PAKs) regulate cytoskeletal dynamics and angiogenesis; however, their roles in vascular reprogramming and chemotherapy responses remain unclear. This stu...

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Autores principales:	Arian Ansardamavandi, Chelsea Dumesny, Sarah Ellis, Ching-Seng Ang, Mehrdad Nikfarjam, Hong He
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2025-11-01
Colección:	Cells
Materias:	pancreatic ductal adenocarcinoma PAK1 knockdown PAK4 knockout tumour vasculature hypoxia endothelial adhesion molecules
Acceso en línea:	https://www.mdpi.com/2073-4409/14/22/1806
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