Dexmedetomidine Enhances Autophagy via α2-AR/AMPK/mTOR Pathway to Inhibit the Activation of NLRP3 Inflammasome and Subsequently Alleviates Lipopolysaccharide-Induced Acute Kidney Injury

BackgroundAcute kidney injury (AKI) is a severe complication of sepsis; however, no effective drugs have been found. Activation of the nucleotide-binding domain-like receptor protein 3 (NLRP3) inflammasome is a major pathogenic mechanism of AKI induced by lipopolysaccharide (LPS). Autophagy, a proce...

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Главные авторы:	Tianyuan Yang, Xiujing Feng, Yuan Zhao, Haiyang Zhang, Hailin Cui, Mian Wei, Haotian Yang, Honggang Fan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Frontiers Media S.A. 2020-06-01
Серии:	Frontiers in Pharmacology
Предметы:	acute kidney injury dexmedetomidine autophagy NLRP3 inflammasome α2-AR/AMPK/mTOR pathway
Online-ссылка:	https://www.frontiersin.org/article/10.3389/fphar.2020.00790/full
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