Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

Abstract Background How exosomal microRNAs (miRNAs) derived from macrophages contribute to the development of drug resistance in the context of the hypoxic tumor microenvironment in epithelial ovarian cancer (EOC) remains poorly understood. Methods The miRNA levels were detected by qRT-PCR. Protein...

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Hlavní autoři:	Xiaolan Zhu, Huiling Shen, Xinming Yin, Meiling Yang, Hong Wei, Qi Chen, Fan Feng, Yueqin Liu, Wenlin Xu, Yuefeng Li
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-02-01
Edice:	Journal of Experimental & Clinical Cancer Research
Témata:	Exosome miR-223 Chemoresistance Macrophages EOC
On-line přístup:	http://link.springer.com/article/10.1186/s13046-019-1095-1
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