Development of a humanized mouse model of graft-versus-host disease to assess human regulatory T cell function

IntroductionRegulatory T cells (Treg)-based therapies are increasingly used for treating autoimmune or graft-versus-host (GVHD) disease. Given their low frequency, several approaches aimed at amplifying them or at increasing their immunosuppressive activities are currently investigated. Unfortunatel...

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Bibliografiske detaljer

Principais autores:	Charline Beguin, Oswin Kwan, Grégory Ehx, Stéphanie Humblet-Baron, Murat Cem Köse, Sophie Dubois, Lorenzo Canti, Justine Courtois, Coline Daulne, Jo Caers, Yves Beguin, Caroline Ritacco, Frédéric Baron
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2025-12-01
Serier:	Frontiers in Immunology
Fag:	GVHD xenogeneic NSG-HLA-A2/HHD regulatory T cells TNF-α single-cell RNA seq
Online adgang:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1717133/full
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