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Molecular architecture of the human tRNA ligase complex

RtcB enzymes are RNA ligases that play essential roles in tRNA splicing, unfolded protein response, and RNA repair. In metazoa, RtcB functions as part of a five-subunit tRNA ligase complex (tRNA-LC) along with Ddx1, Cgi-99, Fam98B, and Ashwin. The human tRNA-LC or its individual subunits have been i...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Alena Kroupova, Fabian Ackle, Igor Asanović, Stefan Weitzer, Franziska M Boneberg, Marco Faini, Alexander Leitner, Alessia Chui, Ruedi Aebersold, Javier Martinez, Martin Jinek
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2021-12-01
Schriftenreihe:eLife
Schlagworte:
tRNA splicing
ligase
unfolded protein response
helicase
x-ray crystallography
Online-Zugang:https://elifesciences.org/articles/71656
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