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Impact of CDK Inhibitors on <i>TBXT</i> Expression in Chordoma Cell Lines Including the First Stable Cell Line of a High-Grade Chordoma

Chordomas are very rare malignant neoplasms of the bone occurring almost exclusively along the spine. As the tumours are thought to arise from notochordal remnants, the vast majority of chordomas express the <i>TBXT</i> gene, resulting in detectable nuclear amounts of its gene product brachyury. Thi...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Sarah Bette, Luisa Haase, Juliane Nell, Thomas Grieser, Alexandra von Baer, Markus Schultheiss, Ralf Marienfeld, Peter Möller, Thomas F. E. Barth, Kevin Mellert
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2024-05-01
Schriftenreihe:Diagnostics
Schlagworte:
chordoma
brachyury
dinaciclib
THZ1
cell line
Online-Zugang:https://www.mdpi.com/2075-4418/14/10/1028
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