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MEN1 promotes ferroptosis by inhibiting mTOR-SCD1 axis in pancreatic neuroendocrine tumors

Pancreatic neuroendocrine tumor (pNET) is the second most common malignant tumors of the pancreas. Multiple endocrine neoplasia 1 ( MEN1) is the most frequently mutated gene in pNETs and MEN1-encoded protein, menin, is a scaffold protein that interacts with transcription factors...

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Principais autores: Ye Zeng, Chen Haidi, Ji Shunrong, Hu Yuheng, Lou Xin, Zhang Wuhu, Jing Desheng, Fan Guixiong, Zhang Yue, Chen Xuemin, Zhuo Qifeng, Chen Jie, Xu Xiaowu, Yu Xianjun, Xu Jin, Qin Yi, Gao Heli
Format: Artigo
Sprog:Inglês
Udgivet: China Science Publishing & Media Ltd. 2022-11-01
Serier:Acta Biochimica et Biophysica Sinica
Fag:
pancreatic neuroendocrine tumor
MEN1
ferroptosis
mTOR signaling
SCD1
Online adgang:https://www.sciengine.com/doi/10.3724/abbs.2022162
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