Predicting gene expression changes from chromatin structure modification
Abstract Spatial organization of chromatin plays a critical role in gene transcription, but connecting population-averaged HiC data to functional outcomes remains a challenge. We present a computational framework linking HiC contact map to gene transcription. Utilizing a bead-spring polymer model in...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2025-04-01
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| Serie: | npj Systems Biology and Applications |
| Accesso online: | https://doi.org/10.1038/s41540-025-00510-4 |
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