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Combined MEK and PARP inhibition enhances radiation response in rectal cancer

Summary: Rectal cancer is frequently diagnosed at a locally advanced stage and treated by neoadjuvant chemoradiation. Current efforts to improve treatment outcome are focused on intensifying neoadjuvant chemotherapy, which is associated with higher levels of toxicity. To discover alternative strateg...

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Principais autores: Qiyun Xiao, Julian E. Riedesser, Theresa Mulholland, Zhenchong Li, Jonas Buchloh, Philipp Albrecht, Xinchen Yang, Moying Li, Nachiyappan Venkatachalam, Olga Skabkina, Anna Klupsch, Ella Eichhorn, Li Wang, Sebastian Belle, Nadine Schulte, Daniel Schmitz, Matthias F. Froelich, Kyrhatii Trikhirhisthit, Erica Valentini, Kim E. Boonekamp, Yvonne Petersen, Thilo Miersch, Elke Burgermeister, Carsten Herskind, Marlon R. Veldwijk, Christoph Brochhausen, Robert Ihnatko, Jeroen Krijgsveld, Ina Kurth, Yuxing Zhu, Yanni Ma, Ke Cao, Michael Boutros, Matthias P. Ebert, Tianzuo Zhan, Johannes Betge
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-08-01
Colecção:Cell Reports Medicine
Assuntos:
rectal cancer
radiation therapy
organoids
drug combination screen
RAS signaling
DNA repair
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S266637912500357X
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