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Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development

Flavin and deazaflavin biosynthesis are highly conserved pathways in mycobacteria, including in Mycobacterium tuberculosis (M.tb). Flavin biosynthesis on one hand is required to produce FMN and FAD, two essential cofactors required to support the flavin intensive lifestyle of mycobacteria. Deazaflav...

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Principais autores: Nurudeen Oketade, Melissa D. Chengalroyen, Dylan Kain, David M. Lewinsohn, Karen M. Dobos
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
Colecção:Frontiers in Immunology
Assuntos:
flavin and deazaflavin
flavin sequestration
MR1T and MAIT cells
mycobacteria
therapeutics
tuberculosis
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1656167/full
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