Flavin and deazaflavin biosynthesis in mycobacteria: relevance to physiology, implications for drug discovery, MR-1 antigenicity, and vaccine development

Flavin and deazaflavin biosynthesis are highly conserved pathways in mycobacteria, including in Mycobacterium tuberculosis (M.tb). Flavin biosynthesis on one hand is required to produce FMN and FAD, two essential cofactors required to support the flavin intensive lifestyle of mycobacteria. Deazaflav...

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Váldodahkkit:	Nurudeen Oketade, Melissa D. Chengalroyen, Dylan Kain, David M. Lewinsohn, Karen M. Dobos
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	Frontiers Media S.A. 2026-01-01
Ráidu:	Frontiers in Immunology
Fáttát:	flavin and deazaflavin flavin sequestration MR1T and MAIT cells mycobacteria therapeutics tuberculosis
Liŋkkat:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1656167/full
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