Dimethyl malonate alleviates obstructive nephropathy by enhancing renal metabolism and inhibiting kidney oxidative stress and inflammation

IntroductionObstructive nephropathy is a leading cause of renal injury and fibrosis. Mitochondrial dysfunction represents a hallmark of obstructive nephropathy, a condition that leads to metabolic aberrations, succinate accumulation, reactive oxygen species (ROS) overproduction, tubular damage, and...

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Autors principals:	Wei Zhang, Changde Fu, Jinjin Lai, Jun Xin, Wenbin Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2025-06-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	obstructive nephropathy dimethyl malonate mitochondria oxidative stress inflammation
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1530635/full
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