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ALKBH3-mediated m1A demethylation promotes the malignant progression of acute myeloid leukemia by regulating ferroptosis through the upregulation of ATF4 expression

To investigate the role of ALKBH3 in acute myeloid leukemia (AML), we constructed an animal model of xenotransplantation of AML. Our study demonstrated that ALKBH3-mediated m1A demethylation inhibits ferroptosis in KG-1 cells by increasing ATF4 expression, thus promoting the development of AML. Thes...

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Principais autores: Xin Liu, Xinghua Pan
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Hematology
Fag:
Acute myeloid leukemia
ALKBH3
m1A demethylation
ATF4
ferroptosis
‌KG-1 cell
Online adgang:https://www.tandfonline.com/doi/10.1080/16078454.2025.2451446
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