PROTAC degraders with ligands recruiting MDM2 E3 ubiquitin ligase: an updated perspective
Mouse double minute 2 (MDM2) is an oncogenic E3 ligase that effectively degrades the tumor suppressor p53. In the past two decades, many MDM2 inhibitors that disrupt MDM2-p53 binding have been discovered and developed. Given that MDM2 and p53 form an auto-regulatory loop, in which p53 undergoes targ...
Na minha lista:
| Principais autores: | , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Compuscript Ltd
2022-05-01
|
| Serier: | Acta Materia Medica |
| Fag: | |
| Online adgang: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0010 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|