Synergistic targeting of eIF4A-mediated translation initiation and apoptosis in acute myeloid leukemia

Abstract: Targeted therapies, such as the BCL-2 inhibitor venetoclax, have expanded the treatment options for patients with acute myeloid leukemia (AML), but survival remains poor because of drug resistance and disease relapse. We found that the translation initiation factor EIF4A1, which unwinds co...

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Bibliografiske detaljer

Principais autores:	Yoke Seng Lee, Jonathan D. Good, Noha Awais, Benjamin K. Eschle, Maia S. Lineberry, Jingting Lin, Mark Wunderlich, Jenna Thibodeau, Holly Edwards, Jessica L. Teo, Sarah Bibeau, Morgan Wollman, George Karadimov, Nurefsan Sariipek, Basit Salik, Jean Acosta, Jenny Noel, David G. J. Cucchi, Erica A. K. DePasquale, Prafulla C. Gokhale, Jerome Ritz, Yubin Ge, Peter G. Miller, Fadi J. Najm, Richard M. Stone, Jacqueline S. Garcia, Andrew A. Lane, Courtney L. Jones, Peter van Galen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2026-05-01
Serier:	Blood Neoplasia
Online adgang:	http://www.sciencedirect.com/science/article/pii/S2950328026000130
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