Synergistic targeting of eIF4A-mediated translation initiation and apoptosis in acute myeloid leukemia

Abstract: Targeted therapies, such as the BCL-2 inhibitor venetoclax, have expanded the treatment options for patients with acute myeloid leukemia (AML), but survival remains poor because of drug resistance and disease relapse. We found that the translation initiation factor EIF4A1, which unwinds co...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Yoke Seng Lee, Jonathan D. Good, Noha Awais, Benjamin K. Eschle, Maia S. Lineberry, Jingting Lin, Mark Wunderlich, Jenna Thibodeau, Holly Edwards, Jessica L. Teo, Sarah Bibeau, Morgan Wollman, George Karadimov, Nurefsan Sariipek, Basit Salik, Jean Acosta, Jenny Noel, David G. J. Cucchi, Erica A. K. DePasquale, Prafulla C. Gokhale, Jerome Ritz, Yubin Ge, Peter G. Miller, Fadi J. Najm, Richard M. Stone, Jacqueline S. Garcia, Andrew A. Lane, Courtney L. Jones, Peter van Galen
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2026-05-01
Edice:	Blood Neoplasia
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2950328026000130
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!