The FABD domain is critical for the oncogenicity of BCR/ABL in chronic myeloid leukaemia
Abstract Background Abnormally expressed BCR/ABL protein serves as the basis for the development of chronic myeloid leukaemia (CML). The F-actin binding domain (FABD), which is a crucial region of the BCR/ABL fusion protein, is also located at the carboxyl end of the c-ABL protein and regulates the...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
BMC
2024-06-01
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| Schriftenreihe: | Cell Communication and Signaling |
| Schlagworte: | |
| Online-Zugang: | https://doi.org/10.1186/s12964-024-01694-8 |
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