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PTN from Leydig cells activates SDC2 and modulates human spermatogonial stem cell proliferation and survival via GFRA1

Abstract Background Spermatogonial stem cells (SSCs) are essential for the maintenance and initiation of male spermatogenesis. Despite the advances in understanding SSC biology in mouse models, the mechanisms underlying human SSC development remain elusive. Results Here, we analyzed the signaling pa...

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Principais autores: Xueheng Zhao, Lvjun Liu, Zenghui Huang, Fang Zhu, Huan Zhang, Dai Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-09-01
Serier:Biological Research
Fag:
Spermatogonial stem cells
Proliferation
Apoptosis
Self-renewal
Pleiotrophin
Syndecan-2
Online adgang:https://doi.org/10.1186/s40659-024-00546-6
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