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Design of chimeric GLP-1A using oligomeric bile acids to utilize transporter-mediated endocytosis for oral delivery

Abstract Background Despite the effectiveness of glucagon-like peptide-1 agonist (GLP-1A) in the treatment of diabetes, its large molecular weight and high hydrophilicity result in poor cellular permeability, thus limiting its oral bioavailability. To address this, we developed a chimeric GLP-1A tha...

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Principais autores: Seho Kweon, Jun-Hyuck Lee, Seong-Bin Yang, Seong Jin Park, Laxman Subedi, Jung-Hyun Shim, Seung-Sik Cho, Jeong Uk Choi, Youngro Byun, Jooho Park, Jin Woo Park
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science (AAAS) 2023-09-01
coleção:Biomaterials Research
Assuntos:
Chimeric peptide
Oral GLP-1 agonist
Oligomeric bile acids
In silico molecular docking
ASBT-mediated endocytosis
Acesso em linha:https://doi.org/10.1186/s40824-023-00421-7
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