Chemical Inhibition of Apurinic-Apyrimidinic Endonuclease 1 Redox and DNA Repair Functions Affects the Inflammatory Response via Different but Overlapping Mechanisms

The presence of oxidized DNA lesions, such as 7,8-dihydro-8-oxoguanine (8-oxoG) and apurinic/apyrimidinic sites (AP sites), has been described as epigenetic signals that are involved in gene expression control. In mammals, Apurinic-apyrimidinic endonuclease 1/Redox factor-1 (APE1/Ref-1) is the main...

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Detalhes bibliográficos

Principais autores:	Thais Teixeira Oliveira, Fabrícia Lima Fontes-Dantas, Rayssa Karla de Medeiros Oliveira, Daniele Maria Lopes Pinheiro, Leonam Gomes Coutinho, Vandeclecio Lira da Silva, Sandro José de Souza, Lucymara Fassarella Agnez-Lima
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-09-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	apurinic/apyrimidinic endonuclease I (APE1) DNA repair transcriptional control inflammation ETS transcription factor
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2021.731588/full
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