The Role of Active-Site Plasticity in Damaged-Nucleotide Recognition by Human Apurinic/Apyrimidinic Endonuclease APE1

Human apurinic/apyrimidinic (AP) endonuclease APE1 hydrolyzes phosphodiester bonds on the 5′ side of an AP-site, and some damaged nucleotides such as 1,N6-ethenoadenosine (εA), α-adenosine (αA), and 5,6-dihydrouridine (DHU). To investigate the mechanism behind the broad substrate specificity of APE1...

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Bibliografische Detailangaben

Hauptverfasser:	Anatoly A. Bulygin, Alexandra A. Kuznetsova, Yuri N. Vorobjev, Olga S. Fedorova, Nikita A. Kuznetsov
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2020-08-01
Schriftenreihe:	Molecules
Schlagworte:	base excision repair AP endonuclease conformational dynamics active site plasticity apurinic/apyrimidinic site 5,6-dihydrouridine
Online-Zugang:	https://www.mdpi.com/1420-3049/25/17/3940
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