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A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate. Here we describe a new rapid and efficient approach for the synthesis of click-based...

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Autori principali: Mamidi Samarasimhareddy, Mai Shamir, Deborah E. Shalev, Mattan Hurevich, Assaf Friedler
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020-05-01
Serie:Frontiers in Chemistry
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Accesso online:https://www.frontiersin.org/article/10.3389/fchem.2020.00405/full
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