The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy

The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (ATRA) in acute myeloid leukemia (AML). We found that ATRA significantly suppressed global translation and protein synthesis in AML cells. The efficacy of ATRA in treating AML required its translationa...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Ke Wang, Ziyao Ou, Ge Deng, Shufang Li, Jingjing Su, Yayun Xu, Renpeng Zhou, Wei Hu, Feihu Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-10-01
Colecção:	Pharmaceutics
Assuntos:	ATRA AML translatome Ribo-seq PI3K/AKT eIF4E
Acesso em linha:	https://www.mdpi.com/1999-4923/14/11/2329
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!