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The Translational Landscape Revealed the Sequential Treatment Containing ATRA plus PI3K/AKT Inhibitors as an Efficient Strategy for AML Therapy

The present study aimed to better understand the possibility of utilizing all-trans retinoic acids (ATRA) in acute myeloid leukemia (AML). We found that ATRA significantly suppressed global translation and protein synthesis in AML cells. The efficacy of ATRA in treating AML required its translationa...

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Principais autores: Ke Wang, Ziyao Ou, Ge Deng, Shufang Li, Jingjing Su, Yayun Xu, Renpeng Zhou, Wei Hu, Feihu Chen
פורמט: Artigo
שפה:Inglês
יצא לאור: MDPI AG 2022-10-01
סדרה:Pharmaceutics
נושאים:
ATRA
AML
translatome
Ribo-seq
PI3K/AKT
eIF4E
גישה מקוונת:https://www.mdpi.com/1999-4923/14/11/2329
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