SIRT1-Dependent Upregulation of Antiglycative Defense in HUVECs Is Essential for Resveratrol Protection against High Glucose Stress

Uncontrolled accumulation of methylglyoxal (MG) and reactive oxygen species (ROS) occurs in hyperglycemia-induced endothelial dysfunction associated with diabetes. Resveratrol (RSV) protects the endothelium upon high glucose (HG); however, the mechanisms underlying such protective effects are still...

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Detalhes bibliográficos

Principais autores:	Silvano Junior Santini, Valeria Cordone, Mahmut Mijit, Virginio Bignotti, Pierpaolo Aimola, Vincenza Dolo, Stefano Falone, Fernanda Amicarelli
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2019-09-01
coleção:	Antioxidants
Assuntos:	oxidative stress glycative stress dicarbonyl stress antioxidant defense superoxide dismutase catalase glyoxalase EX527 sirtuin 1
Acesso em linha:	https://www.mdpi.com/2076-3921/8/9/346
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