The NewroBus platform: engineered humanized anti-TfR1 nanobodies for efficient brain delivery

Abstract Background Delivery of biologic therapeutics to the central nervous system (CNS) is hindered by the blood–brain barrier (BBB), which restricts large molecule passage. Receptor-mediated transcytosis via transferrin receptor 1 (TfR1) provides a physiological route for selective BBB transport....

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Autores principales:	Tao Yin, Metin Yesiltepe, Sanjay Metkar, Aubin Ramon, Matthew Greenig, Pietro Sormanni, Luciano D’Adamio
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-12-01
Colección:	Cell Communication and Signaling
Materias:	TNFα Nanobody Blood–brain-barrier Alzheimer Disease TNFα inhibition Single-domain antibody
Acceso en línea:	https://doi.org/10.1186/s12964-025-02605-1
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