The NewroBus platform: engineered humanized anti-TfR1 nanobodies for efficient brain delivery
Abstract Background Delivery of biologic therapeutics to the central nervous system (CNS) is hindered by the blood–brain barrier (BBB), which restricts large molecule passage. Receptor-mediated transcytosis via transferrin receptor 1 (TfR1) provides a physiological route for selective BBB transport....
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
BMC
2025-12-01
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| Σειρά: | Cell Communication and Signaling |
| Θέματα: | |
| Διαθέσιμο Online: | https://doi.org/10.1186/s12964-025-02605-1 |
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