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Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic target, given PAR4 seems...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Rachel A. Rigg, Laura D. Healy, Tiffany T. Chu, Anh T. P. Ngo, Annachiara Mitrugno, Jevgenia Zilberman-Rudenko, Joseph E. Aslan, Monica T. Hinds, Lisa Dirling Vecchiarelli, Terry K. Morgan, András Gruber, Kayla J. Temple, Craig W. Lindsley, Matthew T. Duvernay, Heidi E. Hamm, Owen J. T. McCarty
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Taylor & Francis Group 2019-01-01
Rangatū:Platelets
Ngā marau:
par4
platelet-leukocyte interactions
platelet dense granule release
platelet activation
protease-activated receptor 4
granulocytes
Urunga tuihono:http://dx.doi.org/10.1080/09537104.2017.1406076
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