Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Human platelets express two protease-activated receptors (PARs), PAR1 (F2R) and PAR4 (F2RL3), which are activated by a number of serine proteases that are generated during pathological events and cause platelet activation. Recent interest has focused on PAR4 as a therapeutic target, given PAR4 seems...

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Autores principales:	Rachel A. Rigg, Laura D. Healy, Tiffany T. Chu, Anh T. P. Ngo, Annachiara Mitrugno, Jevgenia Zilberman-Rudenko, Joseph E. Aslan, Monica T. Hinds, Lisa Dirling Vecchiarelli, Terry K. Morgan, András Gruber, Kayla J. Temple, Craig W. Lindsley, Matthew T. Duvernay, Heidi E. Hamm, Owen J. T. McCarty
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Taylor & Francis Group 2019-01-01
Colección:	Platelets
Materias:	par4 platelet-leukocyte interactions platelet dense granule release platelet activation protease-activated receptor 4 granulocytes
Acceso en línea:	http://dx.doi.org/10.1080/09537104.2017.1406076
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