Knockdown of long non-coding RNA SOX2OT downregulates SOX2 to improve hippocampal neurogenesis and cognitive function in a mouse model of sepsis-associated encephalopathy

Abstract Background Aberrant hippocampal neurogenesis is an important pathological feature of sepsis-associated encephalopathy. In the current study, we examined the potential role of the long noncoding RNA (lncRNA) sex-determining region Y-box 2 (SOX2) overlapping transcript (SOX2OT), a known regul...

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Váldodahkkit:	Jialin Yin, Yanan Shen, Yanna Si, Yuan Zhang, Jiayue Du, Xiajuan Hu, Mengmeng Cai, Hongguang Bao, Yan Xing
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2020-10-01
Ráidu:	Journal of Neuroinflammation
Fáttát:	Sepsis-associated encephalopathy Cognitive dysfunction Hippocampal neurogenesis SOX2OT SOX2
Liŋkkat:	http://link.springer.com/article/10.1186/s12974-020-01970-7
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