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Modulation of NF-κB and cytokine signaling by Cordia dichotoma and Cordia myxa attenuates methotrexate-induced pulmonary inflammation and oxidative injury in rats

BackgroundMethotrexate (MTX) is a widely used anticancer and immunosuppressive agent, but its clinical use is limited by lung injury associated with oxidative stress, inflammation, and fibrosis. Leaves of Cordia dichotoma and Cordia myxa traditionally have been used for respiratory disorders, sugges...

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Principais autores: Nermine M. Mohammed, Hoda M. Hassan, Fatma A. Moharram, Elsayed K. El-Sayed, Asmaa A. Ahmed, Mohamad Elbaz, Merhan E. Ali, Chia-Ying Lin, Kuei-Hung Lai, Shahenda Mahgoub, Hanan G. Sary, Heba T. Khazaal
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2026-06-01
Serier:Frontiers in Pharmacology
Fag:
Cordia dichotoma
Cordia myxa
lung inflammation
methotrexate
oxidative stress
TGF-β1/α-SMA signaling
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2026.1836019/full
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