Mycobacterium tuberculosis VadK is required for the regulation of the methylcitrate cycle and virulence

Abstract The evolution of new enzymatic functions is constrained and guided by the architecture of an organism’s metabolic and regulatory networks and environmental constraints. Here, we identify a kinase that has evolved from pyruvate phosphate dikinase. Using biochemical and systems-level analyses...

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Principais autores:	Jordan Pascoe, Jane Newcombe, Jessica Mendoza, Shalini Birua, Tom A Mendum, Kushi Anand, Albel Singh, Amitava Sinha, Kadamba Papavinasasundaram, Apoorva Bhatt, Gerald Larrouy-Maumus, Amit Singh, Celia W Goulding, Dany J V Beste
Formato:	Artigo
Idioma:	Inglês
Publicado:	Springer Nature 2026-06-01
Series:	EMBO Reports
Acceso en liña:	https://doi.org/10.1038/s44319-026-00818-0
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