The initiator of neuroexcitotoxicity and ferroptosis in ischemic stroke: Glutamate accumulation
Glutamate plays an important role in excitotoxicity and ferroptosis. Excitotoxicity occurs through over-stimulation of glutamate receptors, specifically NMDAR, while in the non-receptor-mediated pathway, high glutamate concentrations reduce cystine uptake by inhibiting the System Xc-, leading to int...
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| Автори: | , , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Frontiers Media S.A.
2023-03-01
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| Серія: | Frontiers in Molecular Neuroscience |
| Предмети: | |
| Онлайн доступ: | https://www.frontiersin.org/articles/10.3389/fnmol.2023.1113081/full |
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