AMP‐activated protein kinase inhibition in fibro‐adipogenic progenitors impairs muscle regeneration and increases fibrosis

Abstract Background Following muscle injury, fibro‐adipogenic progenitors (FAPs) are rapidly activated and undergo apoptosis at the resolution stage, which is required for proper muscle regeneration. When excessive FAPs remain, it contributes to fibrotic and fatty infiltration, impairing muscle reco...

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Autori principali:	Xiangdong Liu, Liang Zhao, Yao Gao, Yanting Chen, Qiyu Tian, Jun Seok Son, Song Ah Chae, Jeanene Marie deAvila, Mei‐Jun Zhu, Min Du
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Wiley 2023-02-01
Serie:	Journal of Cachexia, Sarcopenia and Muscle
Soggetti:	AMPK FAPs fibrosis MMP‐9 obesity TGF‐β
Accesso online:	https://doi.org/10.1002/jcsm.13150
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