A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases

Abstract Background The APOE‐ε4 allele is an established risk factor for Alzheimer's disease (AD). TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 associations with AD that are independent of APOE‐ε4 are at variance. Methods We investigated associations of AD wit...

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Detalhes bibliográficos

Principais autores:	Selma M. Soyal, Markus Kwik, Ognian Kalev, Stefan Lenz, Greta Zara, Peter Strasser, Wolfgang Patsch, Serge Weis
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2020-08-01
coleção:	Molecular Genetics & Genomic Medicine
Assuntos:	Alzheimer’ disease APOE beta‐amyloid genetics haplotypes neurofibrillary tangles
Acesso em linha:	https://doi.org/10.1002/mgg3.1317
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