A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer’s disease in autopsy cases

Abstract Background The APOE‐ε4 allele is an established risk factor for Alzheimer's disease (AD). TOMM40 located adjacent to APOE has also been implicated in AD but reports of TOMM40 associations with AD that are independent of APOE‐ε4 are at variance. Methods We investigated associations of AD wit...

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Главные авторы:	Selma M. Soyal, Markus Kwik, Ognian Kalev, Stefan Lenz, Greta Zara, Peter Strasser, Wolfgang Patsch, Serge Weis
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Wiley 2020-08-01
Серии:	Molecular Genetics & Genomic Medicine
Предметы:	Alzheimer’ disease APOE beta‐amyloid genetics haplotypes neurofibrillary tangles
Online-ссылка:	https://doi.org/10.1002/mgg3.1317
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