Drug discovery of small molecules targeting the higher-order hTERT promoter G-quadruplex.
DNA G-quadruplexes (G4s) are now widely accepted as viable targets in the pursuit of anticancer therapeutics. To date, few small molecules have been identified that exhibit selectivity for G4s over alternative forms of DNA, such as the ubiquitous duplex. We posit that the lack of current ligand spec...
Gardado en:
| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Public Library of Science (PLoS)
2022-01-01
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| Series: | PLoS ONE |
| Acceso en liña: | https://doi.org/10.1371/journal.pone.0270165 |
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